Syntheses of Organic Fluorine Compounds. IV. : Syntheses and Pharmacological Study of Fluorine-substituted Benzhydryl Aminopropyl Ethers
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چکیده
منابع مشابه
Thermochemistry of Organic Fluorine Compounds and Carbon Compounds
Rotating-bomb calorimetry was first applied to organic compounds that contain chlorine, bromine, or sulphur. Techniques developed for these classes of compounds, mostly at the University of Lund and at the Bureau of Mines in Bartlesville, have been described in the book Experimental Thermochemistry-, The development of rotating-bomb methods made accurate combustion calorimetry feasible for othe...
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The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylatio...
متن کاملFacile new syntheses of substituted benzhydryl derivatives using trichloroacetimidate C-C bond formation method
An improved syntheses of substituted benzhydryl derivatives has been developed. This facile two-step procedure involves C-C bond formation from O-diphenylmethyltrichloroacetimidate and C-nucleophiles in the presence of TMSOTf. The C-nucleophiles include arenes, alkenes, alkene silylated C-nucleophiles and trimethylsiloxy alkenes to give a series substituted benzhydryl derivatives in excellent y...
متن کاملSyntheses and reactivity of naphthalenyl-substituted arenediynes.
A series of naphthalenyl-substituted arenediynes were prepared to examine photochemical reactivity. For naphthalen-1-ylethynyl arenediyne, 350 nm photolysis resulted in a tandem [2 + 2] photocycloaddition to afford cyclobutene adducts. For naphthalen-2-ylethynyl derivatives, electron-donating methoxy substituents were found to facilitate C(1)-C(6) Bergman cyclization at 300 nm. Theoretical calc...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1967
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.87.9_1109